![]() ![]() “How do your eyes feel when you wake up?”ġ: good, 2: not good, 3: have difficulty opening, 4: feel foreign body sensation, 5: feel pain, 6: eye discharge, 7: lacrimation, 8: dry, 9: sensitive to light, 10: others, multiple answers allowed “Do you wake up to eye pain during sleep?”ġ: never, 2: once a week, 3: twice to four times a week, 4: every night “How long does it take you to fall asleep after you go to bed?” “At what time do you go to bed during weekdays?” “At what time do you get up during weekdays?” “How would you rate the quality of your sleep?”ġ: great, 2: good, 3: average, 4: not good, 5: poorly “Have you been diagnosed as having DED?”ġ: constantly, 2: sometimes 3: rarely, 4: never “How often do you have a sensation of a foreign body in your eye?”ĭ5. “How often do you feel dryness in your eye?”ġ: constantly, 2: sometimes, 3: rarely, 4: neverĭ4. Preventative eye care for lagophthalmos before and during sleep may be helpful for DED and sleep quality.ĭ3. The current study suggested that NL was associated with worsened DED symptoms and poor sleep quality. ![]() Logistic regression analysis showed that NL correlated with younger age, symptomatic DED, and eye symptoms upon waking. NL was more prevalent in the DED group ( p = 0.007). Furthermore, people belonging to the DED group were more frequently working night shifts ( p < 0.001). Sleep duration was significantly shorter ( p = 0.008), sleep latency was longer ( p < 0.001), and sleep efficacy was worse compared with the non-DED group ( p < 0.001). The DED group was comprised of 890 subjects (44 ± 13.8 years, 359 males) and women were predominant ( p < 0.001). Participants were divided into two groups according to the presence of DED, and responses were compared between the groups. The participants were asked to answer a questionnaire about DED, sleep quality, and happiness. We launched a survey website to recruit 2000 Japanese. This study aimed to evaluate the prevalence of NL and sleep quality in DED patients. To reduce the chances of having Nocturnal Lagophthalmos, it is important to have healthy sleep habits like aiming for 7-8 hours of sleep each night, and avoiding alcohol or sleeping pills before bed.Nocturnal lagophthalmos (NL) refers to the inability to close the eyelids during sleep, which is known to affect dry eye disease (DED) symptoms and sleep quality. ![]() Depending on how severe the condition is, some people may need a more invasive treatment option, such as a surgery to physically move the eyelids closer to one another so that they are more likely to shut.This is done by enlarging either the top or bottom eyelid. There are many easy options for managing this condition, such as using eye drops to keep the eyes moistened, using a sleeping mask, gently taping the eyelids shut at night, or applying small weights to the eyelids at night to keep them shut. Some of the symptoms associated with this condition include dry eyes, sensitivity to light after waking, red eyes, and/or blurred vision. Nocturnal Lagophthalmos is not dangerous in itself however, it can lead to vulnerability of the eye for injuries or scratches, because the eyelid is not fully protecting the eye. This condition may be caused by several factors, including protruding or deeply sunken eyes and cosmetic surgery on the eyelids, to more serious factors like damage to the facial nerve due to stroke, autoimmune disease, or hyperthyroidism. The eyelids protect the eyes from foreign substances and they close during sleep to prevent the eyes from becoming dry, which could cause complications and discomfort. Nocturnal Lagophthalmos is a condition where a person does not completely close the eyelids during sleep. ![]()
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![]() A Boxer has a large head that still appears balanced with a broad, shortened muzzle and an undershot jaw. Even a larger individual should give the impression of being a medium-sized, compact, squarely built dog. Females can be significantly smaller than males. Physical Appearance of Boxersīoxers are medium to medium-large, standing 22 to 25 inches tall at the shoulders and weighing 50 to 80 pounds. ![]() The AKC had accepted the late-blooming Boxer in 1904. Some experts contend the Boxer was the result of last-ditch efforts to reinstate the “bull biters.” Boxer puppies for sale gained popularity in the US with a show dog called Bang Away in the 1950s, and the breed never looked back. Like the Old English Bulldog, the Bullenbeisser became extinct in the early 1900s through crossbreeding. Bullenbeissers were strong, agile, versatile dogs used for hunting, guarding, bull-baiting, dog fighting, and catching livestock. Boxers developed from the smaller dogs or Brabanter Bullenbeissers. Smaller dogs were 40 to 60 pounds, and the larger ones were 70 to 100 pounds. Thought to have arrived from Asia around 370 AD, two lines eventually emerged in Europe. Bullenbeissers are now extinct but resembled Old English Bulldogs. Originally the Boxer was a cross between a Bullenbeisser, or German Bulldog, and various other breeds such as the Great Dane, English Bulldog, sundry terriers, and the Mastiff. Boxer Puppies for Sale About the Boxer Historyīoxers came from Germany. Boxers thrive with owners who are active, adventurous, and willing to carve out plenty of activities for a boisterous dog. With its flashy looks, athletic abilities, and winning personality, a Boxer makes a good companion for single people, couples, or families with children over nine years old. He has participated in the military, the police force, hunting, cattle driving, guiding the blind, and guarding the home. ![]() The Boxer is both elegant and dignified yet not above silly antics. Few dogs can pull off acting like a clown and looking intimidating at the same time. Having one of the most lovable faces, the Boxer wears many hats. Boxer puppies for sale near me under $500īoxer puppies for sale under $1,000 Flash, Brawn, and Personality: Boxer Puppies for Sale Have it All ![]() ![]() Kyle's primary responsibility at RA is to lead investments in private companies that are developing innovative solutions to address climate change and environmental sustainability. Kyle Teamey joins RA Capital as a Managing Partner, Planetary Health. Brigid holds a BS in Chemistry (Hons) from the Commonwealth Honors College at the University of Massachusetts, Amherst (2002) and a PhD in Materials Science and Engineering from Johns Hopkins University (2009). Prior to BHP, Brigid was at In-Q-Tel (IQT), the strategic investment arm of the CIA and the US Intelligence Community she co-founded IQT's Australian subsidiary, served as its Managing Director, and built an international program to support a global innovation initiative through investing in the Asian-Pacific region. Brigid was responsible for starting the venture fund and led investments in multiple sectors, including advanced analytics platforms, biomining and bioremediation, novel chemical leaching, long-duration energy storage, traceability of products, carbon removal, and green steel. Prior to joining RA, Brigid was the Head of Venture Investments for BHP Ventures, the internal venture capital unit within the world’s largest mining company, where her investment mandate was to help the decarbonization of BHP’s operations and to improve the sustainability of resource extraction. Brigid's primary responsibility at RA is to lead investments in private companies that are developing innovative solutions to address climate change and environmental sustainability. Josh is currently a faculty member at Harvard Medical School and continues to practice medicine as an attending physician in the Department of Emergency Medicine at Massachusetts General Hospital.īrigid O’Brien joins RA Capital as a Managing Partner, Planetary Health. Prior to MRL Ventures, Josh was a Venture Partner with Atlas Venture and a Partner at Prism Venture Partners, focusing on company formation and seed and Series A investing. Before SV, Josh was President and Managing Partner at MRL Ventures Fund, the early-stage therapeutics-focused corporate venture fund within Merck & Co. Josh was previously co-lead of SV Health Investors’ US Biotech practice where he was responsible for SV’s US venture creation activities, including its incubator, Brahma Discovery. He has more than 15 years of experience in investing, company formation, and company leadership across all stages of drug development, from discovery through commercialization. Josh holds a BA in Chemistry from Williams College, an MD from the University of Pennsylvania School of Medicine, and an MBA from the Wharton School of Business. Josh’s primary responsibility at RA Capital is to lead early-stage private investments in and oversee the creation of new companies developing drugs, medical devices, diagnostics, and research tools. Josh Resnick is a Senior Managing Director at RA Capital Management. He holds a BA from Cornell University and a PhD in Virology from Harvard University. Peter founded and serves as a Director of No Patient Left Behind, a non-profit advocate for healthcare reforms that would make today's medicines affordable to patients and promote the innovation that gives all of us hope for tomorrow. He served on the Board of Global Science and Technology for the National Academy of Sciences, is the author of The Entrepreneur’s Guide to a Biotech Startup, and frequently writes and speaks on the future of biotechnology innovation. Peter also leads the firm’s engagement and publishing efforts, which aim to make a positive social impact and spark collaboration among healthcare stakeholders, including patients, physicians, researchers, policymakers, and industry. Peter is active in both public and private investments in companies developing drugs, medical devices, diagnostics, and research tools and serves on the boards of publicly- and privately-held life science companies. Peter Kolchinsky is a founder and Managing Partner at RA Capital Management and author of The Great American Drug Deal. ![]() ![]() ![]() Mario Maker levels: 12 screens long by 2 screens tall, the longest Knowing what others have-in my humble opinion successfully-chosen gives a nice starting point a priori for projects with similar scope. I find choosing an aesthetically pleasing aspect ratio to be a crucial design decision one that I often approach on a trial and error basis. So the Shovel Knight screen is 25 x 15 tiles. SOTN: 356 pixels wide, tiling pattern consists of 16x16 blocks tiling with 16 colors each. More modern resolutions considered: –gamedev-14723 For reference, Link’s sprite in Legend of Zelda, an NES game, is 16 x 16, Link’s sprite in Link’s Awakening, a gameboy game, is 16 x 16, and Link’s sprite in A Link to the Past, an SNES game, is 32 x 32.ĭisplay resolution: 320×224 (many games only used the centermost 304 pixels)Ĭolor palette: 65,536 (16-bit) (Not RGB565, but RGB666, where the lowest bit of each channel is shared with one bit) Typical NES background tiles are 16 x 16 pixels, foreground sprites are either 8 x 8 or 8 x 16 (Sources: ). The Gameboy is 160 x 144 according to #gbajam. They shoot for is 400 x 240, resulting in an aspect ratio of 5:3.Īccording to the fine article and wikipedia, that’s pretty close to a stretched out version of the original NES resolution.įor no other purpose than my own reference here, the DS’ resolution is 256 x 192, according to this article. It also mentions that the effective resolution The fine article mentions that scaling Shovel Knight’s NES-style graphics up to 1080p results in virtual pixels of about 4.5 x 4.5 1080p pixels. Shovel Knight runs on displays meant to run 1080p down to pocket-sized 3DS screens. The interview starts about 28 minutes into the podcast. Interview with the Shovel Knight creators Yacht Club Games. Great article about parallax scrolling and plenty of other stuff from Shovel Knight: Įven some indies are getting into the spirit: Here’s a collection of relatively disorganized notes looking at Shovel Knight’s design. ![]() ![]() Those exposed fasteners, for example, will need to be checked and tightened over time. However, corrugated roofs require more maintenance than standing seam roofs. Their fasteners are exposed, unlike with standing seam. Because of their design, corrugated roofs are easier to install. CorrugatedĬorrugated roofs are about half the cost of standing seam roofs, or $350 to $1,500 per square. This is a popular roofing style, thanks to its modern aesthetic. Thickness ranges from 18 to 28 gauge and material types include galvanized steel, galvalume steel, aluminum, copper, and zinc. The width ranges from 12 inches to 30 inches per panel and each square is cut to the actual size of your roof. This is an expensive yet highly customizable option for residential and commercial use. The most expensive metal roof style is standing seam standing seam metal roofs cost $700 to $3,000 per square. ![]() These steel panels offer painted and unpainted options to suit diverse aesthetic needs. Metal panels derive from galvanized or galvalume steel at a 24- to 30-gauge thickness and tend to feature exposed fasteners. Sheet metal roofs are typically the most affordable style of metal roof. Sheet metal panels cost $400 to $650 per square. Metal roofs can range in price per square, from $400 to $3,000, but the cost depends on more than just the type of roof. Although it develops a protective rust layer, it is not recommended for coastal residences. This roofing material is popular for its weathered, rustic look. This roof type is commonly called by the brand name, Corten Steel. RustedĪ rusted metal roof costs $9 to $15 per square foot, or $900 to $1,500 per square, installed. Manufacturers have conducted studies to show that this material is safe, but check with your installer, the Environmental Protection Agency (EPA), and/or your state legislature for restrictions and regulations. It’s highly malleable and resists corrosion. When properly maintained, lead roofs can last 100 years or more. The copper alternative is lighter-weight. Many of today's lead products have an alternative core, such as copper, and a lead coating. Lead roofing costs $1,000 to $1,500 per square, installed. If properly maintained, a zinc roof can last 100 years or more. It forms a coating as it weathers that protects the zinc and reseals if it suffers dings or scratches. Zinc is a naturally occurring material that can actually "heal" itself. The shingle style is lower in cost you’ll pay more for a standing seam zinc roof. Zinc roofing costs $600 to $1,200 per square, installed. Their core material is actually steel and only the coating contains tin in a zinc/tin or lead/tin alloy. Today’s popular tin products are known as Terne. To prevent rust and erosion over time, you’ll need to pay for maintenance-but when properly maintained, a tin roof can last up to 70 years. Tin roof installation costs $500 to $1,200 per square. For example, stainless steel is on the Chrysler Building in New York City. Stainless steel is a durable, corrosion- and rust-resistant alloy with an excellent track record. Stainless steel roofs cost $1,000 to $1,600 per square, installed. These roofs are low-maintenance and energy-efficient, but they aren’t as corrosion-resistant. ![]() This makes them more expensive than galvalume (but less expensive than stainless steel). Galvanized steel roofs have a steel core and a zinc coating for rust resistance. Galvanized steel roofs cost $750 to $1,000 per square, installed. You can get galvalume in a variety of colors, but it’s subject to fading. This rust-resistant, highly pliable roof is the lowest-cost option for steel roofs. Galvalume steel roofs cost $600 to $900 per square, installed. Various steel types include galvalume, galvanized, and stainless steel. Steelĭepending on the type of steel, a steel roof cost can range from $600 to $1,600 per square. Over time, it develops a corrosion-resistant patina. That said, copper is long-lasting ( 100+ year lifespan), low-maintenance, and resistant to rust. A 3,000-square-foot project with the most expensive copper material in the most expensive labor market could theoretically cost more than $90,000, but a 2,000-square-foot copper roof project costs an average of $42,000.Ĭopper is difficult to work with and demands professional installation. CopperĬopper roofing costs between $1,500 and $3,000 per square. They can keep utility costs down thanks to their high natural reflectivity in fact, aluminum is among the most energy-efficient roofing materials. Aluminum roofs can last 45 years and are recyclable and highly pliable. You can get aluminum in sheet or shingle form. ![]() For a 2,300-square-foot home, an aluminum roof could cost from $9,200 to $25,300, but a smaller 1,000-square-foot home could cost as low as $4,000 installed. Installing an aluminum roof costs from $400 to $1,100 per square. Find hiring guides, material costs, expert advice, how-to's and more. ![]() ![]() ![]()
![]() Cambridge - A open-source game with options for custom modes, rulesets, and more.Notris Foes - An on-going fan-made client project of Tetris Friends.Worldwide Combos - A multiplayer "1 versus 1" game, where you have to knock out your opponent as many times as possible within the time limit.Tetris Online Poland - Fan-operated server for the defunct Tetris Online Japan: Minna de Tetris.Cultris II - Fast and furious combo attacking with some old-school flair.Jstris - Streamlined web client for modern-style Versus, 40 Lines, and Cheese.TETR.IO - A modern online stacker, with leaderboards and various single player and battle modes.- A simple official modern Tetris® game with 300-line Marathon mode available online via a web browser.Tetris® 99 - Face-off in an epic battle royale available on Nintendo Switch. ![]() Puyo Puyo Tetris® 2 - Block-stacking meets Puyo-matching with a character-driven storyline and a variety of modes available on PS4/PS5, XBOX Series X/S, Windows (Steam), and Nintendo Switch.Tetris® Effect: Connected - A visually stunning game with plenty of single-player and multiplayer modes available on PS4, XBOX Series X/S, Windows (MS Store/Epic Games/Steam), Oculus Quest, and Nintendo Switch. ![]() ![]() See the Tetris wiki at tetris.wiki Other Resources Want to meet other Tetris players of your kind? Need real-time gameplay advice? Join these communities today!įor The Grand Master (TGM) Tetris players: ![]() ![]() ![]() A direct sequel continues the story directly from where it ended in the original work.Īn indirect sequel is set in the same world as the original work but has no direct connection to it. Or even if it’s a sequel at all! What Is A Sequel? If a sequel’s cast is entirely new or only has one or two returning actors, this can affect whether people see it in theaters or not. In general, sequels are typically not as critically acclaimed as their predecessors because they don’t bring anything new to the table, but many die-hard fans enjoy seeing their favorite characters again.Ī sequel should generally retain most of its predecessor’s cast. Frank Baum became inspired to write The Wizard of Oz. This was directed by Sam Raimi and told the story of how L. ![]() It can also be a retelling of the same story from a different perspective, like the 2013 film, Oz: The Great and Powerful. The backstories of characters are often revealed in sequels, such as what happened after a character dismissed a love interest in the previous film.Ī sequel doesn’t always have to continue from where a film left off. ‘Tent pole’ movies (read: expensive productions) have sequels to keep the franchise going and to earn more money for the creators. A sequel may be an individual story, or it can tie into the overall storyline. If I were a referee or even a copyeditor, I would almost certainly let the author use "in the sequel" if she wants.A sequel or follow-up is the second film based on a popular or successful movie that is made by the same director, producers, and actors. Most people agree that good mathematical writing is as stylistically unobstrusive as possible, so using phrases that make people ponder and ask questions about them on websites is, arguably, slightly too distracting.Īnyway, it's no big deal. beginning a sentence with "Remark that." sounds a little stilted and is probably a semiconscious translation of the french phrase "Remarquer que" (which I would translate as "Notice that"). If you read enough math papers you'll find that there are certain linguistic ticks that people pick up from each other (and also sometimes, from writing in other languages), e.g. Second, in my opinion it is somewhat hackneyed language and an idiomatic usage that doesn't add any meaning. First, as Mariano says, nowadays we hear "sequel" used most commonly for the next movie in a franchise, so its use in a math paper will inevitably make some readers think that you are referring to Part II: This Time, It's Personal, or whatever. Also its meaning should be relatively transparent to a literate native speaker of English: this is after all what the dictionary says that "sequel" means. Ths phrase is, as you point out, rather common, so any experienced reader of math will have seen it before. On to your question of whether this is acceptable usage in a math paper: acceptable, yes, but not completely recommended. Your interpretation of how "in the sequel" is used in mathematical literature is correct: it means "in what follows", "in the remainder of the present text", "from now on".As you can see, there are many other such expressions, and I don't think that "in the sequel" has any particular nuance of meaning that these other phrasings lack. In the main text of the paper or book? Finally, out of curiosity, I'm wondering how long this phrase has been around, if it's considered out of date or if it's still a popular phrase, and what some good alternatives are. "Īt the start of a paper or book without a formal "In the sequel, we introduce the concept of a "blah", which is a thing satisfying. )Īt what points in the text, and for what kinds of X, is it appropriate to use the phrase "In the sequel, X" in a paper? In a book? Is it ever acceptable to introduce definitions via (Someone recently argued to me that "sequel" was actually supposed to refer to a forthcoming second part of a paper, which I found highly unlikely, but I'd just like to make sure. While I feel quite confident that I've inferred the correct meaning of "In the sequel" from context, I've never heard anyone explicitly tell me, so first off, to remove my niggling doubts: What does this phrase mean? ![]() ![]() ![]() I'm not a fan of spending twice as much effort to make a finish look old. Every panel will likely get proper attention to both sides. Paint is currently not bad at all with only a couple very minor surface rust spots and the dullness that comes with age. Once lowered, if I don't think the length hurts it visually, I'll leave it. I originally wanted a shorty, but they are starting to look a bit toy-like to me. Likely no larger than 16s and they will have a little more sidewall than most on here are used to seeing. I'm leaning towards a decidedly truck looking setup, but something modern is not out of the question. Wheels will be sorted out once the stance is set. My daughter is most concerned with the tunes situation.I'm certain that will get worked out.Ī/C will be a must. It may get some hush matt and carpeting and will absolutely be getting 3 point belts. Interior will remain stock and is in very good condition. If that is the case, a C6 would be the easiest, but I'd hate to ignore a more modern overdrive unit. Transmission may get changed to an automatic. If it gets a 4-link, it will likely get bags or adjustable springs so it can be adjusted to haul a load if needed. I may go with a 4 link, but that is undecided. If it remains sprung with leafs, they'll at least be hung below the axle with Calvert perches. I'll sort out the bolt pattern issue either with axles or re-drilling. I'm a muscle car guy and a weenie Exploer rear end won't do. ![]() The 5/8" spacer normally put on top of the frame rails will go UNDER the rails to keep the drop to a minimum of about 4.5 inches. However.Neither I nor my daughter care for the completely slammed look. Power steering, front disks and IFS will be a single event upgrade in the form of the popular Crown Victoria front crossmember swap. Truck will remain with me when she goes off to college.then all bets are off on the motor. All of the engine stuff is last on the list simply because it currently runs great and my daughter doesnt need a tire thrashing animal. Heads may get replaced with Edelbrocks, simply because its not much more money than reworking old iron heads and ends up being a good diet plan. I have an original PI intake that will likely get used and may get topped with an FITech injection setup. It may not remain a 360 with a 2 barrel, but it will remain an FE. Very straight truck with just a couple dings in the stainless trim.Įngine will remain an FE. The cab extension collected water after the fuel filler grommet dried and allowed water in. I assume the old guy drove a lot of dirt roads in Kentucky. The supports had accumulated clay and dirt. Not the cab corner, but the flat panel that extends down behind the cab. The only rust was found in both of the lower floor support brackets and the driver's side rear lower cab. Oh, and there is amosr zero rust on this thing. It runs and drives better than you would expect for ANY 1970 vehicle. It was bought by someone that quickly ended up in cash trouble building a new house and then I stepped in.Īll I have done so far is put new tires on it, service the brakes and carb and throw new plugs and wires on it. At 82, he had now given up driving a longbed with manual steering and 3 on the tree. The original owner had it until a few months ago and kept it garaged its entire life. I responded to a classified ad on and ended up buying a 1970 lwb Ranger F100 time capsule in June, 2016. About a year ago, I started looking on Craigslist and along every backroad I found myself on. I told her it had to be a Ford and had to have an FE. My daughter Ellen is 14 years old and wants an old truck for her first vehicle. I'm into FE engines and own a 66 Cyclone GT with a 428. ![]() This is just an intro for now along with some build guidelines. ![]() ![]() ![]() Telltale games have often had criticism for bad frame rate and stuttering but that’s not the case here, at least with my experience. The recipe menu helps you do this so its never too challenging. One of my favourite things taken from the Minecraft game was the ability to collect items, which give you the chance to craft items that will help you advance through the story. The only challenge The Order of the Stone does present is in quick time events and dialogue options. The gameplay is mixed and keeps things interesting by adding action sequences, where you evade obstacles and encounter enemies. Those conversation choices often translate into story direction choices, as with past Telltale games. The choices you make impact what happens later in the game, this is another good way to add replayability to a game. Be careful how you answer, as it will affect the choices you make and the story going forward. You start off with an intro sequence, and then every so often you’re tasked with choosing a conversation response to move the story along. I think that Mojang and Telltale have done a fantastic job of creating an experience that reflects both Telltale’s formula of gameplay and Minecraft’s style very well. I haven’t really been enticed to play Minecraft in the past, but I’m pleased to have started my journey with Minecraft Story Mode and I can see it increasing sales on the already outstandingly massive sales of Minecraft. I ended up completing it in around ninety minutes, which is comparable to a kids film. I have only really played the first season of The Walking Dead and wasn’t sure how long the first episode would take me. This is nice as it adds replayability to the game. Find out how the choices you made stacked up against others who played. Of course, at the end of the episode you’ll see how your choices stacked up against everyone else who played. The story at first didn’t really seem that interesting but by the end of the first episode things really start to ramp up and we get to see some character development. I enjoyed how the first episode is broken into different segments that not only move the narrative forward, but also changes up gameplay. But everything isn’t as it seems and you run into Ivor. You, as Jesse, and your friends travel to EnderCon hoping to finally win the building competition and secure a spot in being able to meet Gabriel, Warrior of the legendary The Order of the Stone. You can play as a male or female, who is called Jesse. You start the game by selecting your character. The first episode in this series is called The Order of the Stone. Telltale is known for creating episodic point-and-click adventure games, such as The Walking Dead, Game of Thrones and Borderlands. Available on consoles, PCs, and mobile devices, there are plenty of ways to play it. Minecraft is simple and has proved to appeal to adults and children alike. I have to admit I have only tried Minecraft a few times and have never really jumped in fully so it was interesting to see Telltale take a game that really isn’t known for having a narrative and creating an experience that tells a story. Minecraft is the latest franchise Telltale Games has taken on in its episodic style game series. ![]() |
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